1-2-3-LQTS-Risk		  
 
RR Interval
QT Interval
QTc Interval

ms

ms

ms

Insert:

    • QT interval, measured in lead DII or V5 at stable heart rates close to 60 beats/min and RR interval
or
  • QTc interval corrected with Bazett formula.
Genotype:

LQT1
LQT2
LQT3

Patient is a carrier of a single mutation in one of the major LQTS genes:

  • KCNQ1 (LQT1)
  • KCNH2 (LQT2)
  • SCN5A (LQT3)

Life-threatening arrhythmic event is defined as (1) sudden cardiac death, (2) aborted cardiac arrest, and (3) hemodynamically non-tolerated polymorphic ventricular tachycardia.

References

Mazzanti A, et al. Interplay Between Genetic Substrate, QTc Duration, and Arrhythmia Risk in Patients With Long QT Syndrome. J Am Coll Cardiol. 2018 Apr 17;71(15):1663-1671.

Mazzanti A, et al. Independent validation and clinical implications of the risk prediction model for long QT syndrome (1-2-3-LQTS-Risk). Europace. 2022 Apr 5;24(4):614-619.